Vi antigen from Salmonella typhosa and immunity against typhoid fever. I. Isolation and immunologic properties in animals.
نویسندگان
چکیده
The role of Vi antigen in human immunity against typhoid fever has been debated for decades. Circumstantial evidence indicates that Vi antigen may play a role in pathogenicity and immunity. A Vi preparation was isolated from Salmonella typhosa, the causative organism in human typhoid fever, by a mild precipitation method. It was significantly more potent in animal studies than preparations from Citrobacter used in the past for human study and less toxic than conventional typhoid vaccines. With this antigen, the role of Vi antigen in human protection is now being investigated.
منابع مشابه
Vi antigen from Salmonella typhosa and immunity against typhoid fever. 11. Safety and antigenicity in humans.
Safety and antigenicity of a purified preparation of Salmonella typhosa Vi antigen was evaluated in human volunteers. Dosages of Vi antigen at 25, 50, and 100 mug were less toxic than U.S. standard typhoid vaccine (lot 6A) containing 5 X 10(8) bacteria per dosage. Vi antigen in comparison with the standard typhoid vaccine induced higher hemagglutinating antibody but lower bactericidal antibody ...
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Tully, Joseph G. (Walter Reed Army Institute of Research, Washington, D.C.) and Julius A. Currie. Vi-negative strains of Salmonella typhosa: attempts to induce W-V reversion and the use of non-Vi strains in evaluating typhoid vaccines. J. Bacteriol. 84:747-753. 1962.-Repeated attempts have been made to detect reversion of several W-form Salmonella typhosa strains to Vi antigen-containing cultur...
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Salmonella typhimurium hybrids expressing the S. typhosa antigens 9, d, and Vi were constructed by genetic crosses with an S. typhosa Hfr donor. The hybrids retained the same degree of mouse virulence as their S. typhimurium parent strain, the minimum lethal dose being less than 50 organisms when tested either in C(57) black mice or Swiss white mice. Vaccination of the Swiss white mice with S. ...
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Since the early days of immunology, it has been considered that high viru-lence and recency of isolation from pathological material were essential attributes of strains of bacteria to be used in production of superior immunizing agents. In spite of a surprising paucity of supporting factual information this concept has pesisted. Perhaps in no field of investigative immunology has the theory of ...
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عنوان ژورنال:
- Infection and immunity
دوره 9 2 شماره
صفحات -
تاریخ انتشار 1974